The sickle cell trait is found in a recessive allele of the hemoglobin gene. 3. In areas where the malaria parasite is present, both individuals who are homozygous with respect to the sickle cell allele (who will suffer from sickle cell anemia) and individuals who are homozygous with respect to the normal hemoglobin allele (who may contract malaria) have a selective disadvantage. Individuals who are heterozygous for the sickle cell allele have a selective advantage because they are protected from malaria and do not suffer from anemia. 4. Dr. Allison predicted that protection against malaria is correlated with sickle cells. After taking samples, she found that the children with the sickle cell allele had a lower parasite count , as if they were partially protected against malaria 5. As researched, the populations with the highest rate of sickle cell disease is in the areas where malaria is more prone, I think that sickle cell disease could be an evolutionary response that would develop a certain niche of the population, as a defense against malaria. As technological advances develop many alternatives to avoid and perhaps eradicate malaria, I think that people in these areas will evolve by modifying their receptive genes, which were what protected them from malaria, and little by little by evolution the gene that carries this mutation would be eliminated. 6. Inbreeding is defined as “crossing between individuals of a genetically isolated race, community, or population” is technically characterized as the homozygous condition of genes at a particular chromosomal site (locus). Inbreeding causes a deleterious effect on populations of living organisms that present it. Most genetic diseases occur when two faulty genes, which are usually recessive, come together. This means that for a person to have it, both parents must be carriers. Most of us carry a gene for some condition that we will probably never manifest. But if we have a child with a person who also carries that gene, there is a high chance that they will develop a disease that could even lead to death. the effects of inbreeding on the population would consequently be more defective genes and little genetic diversity. 7. The effect that inbreeding would have on the sickle allele would certainly be to increase it. Since it is in a recessive allele, it would not normally have much of a chance of being inherited even more if it is in a heterozygous allele. As a consequence of inbreeding, recessive homologous alleles would be inherited, increasing the reproduction and inheritance of defective genes.
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